2020 The Chinese Society of Biochemistry and Molecular Biology, Gene Division, Secretary

1. The Ministry of Science and Technology of China, 2023/12-2028/11, The structural basis, regulation mechanism, and therapeutic targeting of histone modifiers and DNA methyltransferases.
2. Shanghai Pilot Program for Basic Research，Chinese Academy of Science, Shanghai Branch,2022/01-2026/01
3. The Strategic Priority Research Program of the Chinese Academy of Sciences, 2020/01-2024/12, The crosstalk mechanism of epigenetic regulators
4. The National Natural Science Foundation of China, 2020/01-2023/12/31, Molecular mechanisms of epigenetic regulation by SET1-family histone methyltransferase complex in the fate determination of embryonic stem cells
5. The National Natural Science Foundation of China, 2017/01-2020/12, Structural and functional studies of SWI/SNF-family chromatin remodeling complex
6. The National Natural Science Foundation of China, 2015/01-2018/12, The structural basis for activity regulation of SET1-family histone methyltransferase
7. The Ministry of Science and Technology of China,2013/01-2017/12, The mechanisms by which protein complexes regulate chromatin structure
8. The Strategic Priority Research Program of the Chinese Academy of Sciences, 2014/01-2018/01, Structural and functional studies of telomerase complex and chromatin remodeling complex
9. The Basic Research Project of Shanghai Science and Technology Commission, 2014/09-2017/08, The molecular mechanism of crosstalk between non-coding RNA and MLL-complex

2016 　　　Outstanding Mentor Award, CAS

2018 　　　Outstanding Mentor Award, CAS

2020 　　　Outstanding Mentor Award, CAS

2022 　　　Outstanding Mentor Award, CAS

1. Wenqi Sun#, Qianhua Dong, Xueqing Li, Jinxin Gao, Xianwen Ye, Chunyi Hu, Fei Li*, Yong Chen* (2024) The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B, Nature Communications, 15, 4322
2. Yanjing Li#, Lijie Zhao#, Yuebin Zhang#, Ping Wu#, Ying Xu, Jun Mencius, Yongxin Zheng, Xiaoman Wang, Wancheng Xu, Naizhe Huang, Xianwen Ye, Ming Lei, Pan Shi, Changlin Tian, Chao Peng*, Guohui Li*, Zhijun Liu*, Shu Quan*, Yong Chen* (2022) Structural basis for product specificities of MLL family methyltransferases, Molecular Cell, 82, 3810-3825
3. Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen (2022) DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, iScience, 25(9): 104948
4. Duo Wang#, Fuxiang Yan#, Ping Wu#, Kexue Ge, Muchun Li, Tingting Li, Ying Gao, Chao Peng*, Yong Chen* (2022) Global profiling of regulatory elements in the histone benzoylation pathway, Nature Communication, 13：1369
5. Guochao Chen#, Duo Wang#, Bin Wu#, Fuxiang Yan, Hongjuan Xue, Shu Quan, Yong Chen* (2020) Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Nature Communication, 11:4206
6. Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwei Li, Ying Xu, Yong Chen* (2019) The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 47(19):10426-10438
7. Chunyi Hu^#, Haruna Inoue^#, Wenqi Sun^#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 47(3): 1573-1584 (*co-corresponding author)
8. Qing Li^#, Yanjing Li^#, Suming Yang, Shuo Huang, Meng Yan,  Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen* and Jinsong Li* (2018) CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell Biol. 20(11): 1315-1325 (*co-corresponding author)
9. Chunyi Hu ^#, Rekha Rai ^#, Chenhui Huang, Cayla Broton, Juanjuan Long, Ying Xu, Jing Xue, Ming Lei* , Sandy Chang* and Yong Chen*（2017）Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 27(12):1485-1502  (*co-corresponding author)
10. Yanjing Li, Jianming Han, Yuebin Zhang, Fang Cao, Zhijun Liu, Shuai Li, Jian Wu, Chunyi Hu, Yan Wang, Jin Shuai, Juan Chen, Liaoran Cao, Dangsheng Li, Pan Shi, Changlin Tian, Jian Zhang, Yali Dou, Guohui Li*, Yong Chen^*, and Ming Lei*(2016) Structural basis for activity regulation of MLL family methyltransferases，Nature, 530，447-452 (*co-corresponding author)
11. Yong Chen^# , Rekha Rai^# , Zi-Ren Zhou , Junko Kanoh , Cyril Ribeyre , Yuting Yang , Hong Zheng , Pascal Damay , Feng Wang , Hisayo Tsujii, David Shore , Hong-Yu Hu , Sandy Chang* and Ming Lei* (2011) A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Nat. Struct. Mol. Biol., 18(2): 213-221
12. Yong Chen, Yuting Yang, Megan van Overbeek, Jill R. Donigian, Paul Baciu, Titia de Lange, Ming Lei (2008) A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins. Science, 319: 1092-1096
13. Yong Chen, Yuting Yang, Feng Wang, Ke Wan, Kenichi Yamane, Yi Zhang, Ming Lei (2006) Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc. Natl. Acad. Sci. U S A. 103:13956-13961