1. CAS
  2. CEMCS
  3. CN
  1. Kangjunjie Wang#, Min Chen#, Shukun Yan#, Ying Han, Huairui Yuan, Qiuli Liu, Dayun Lu, Long Li, Kaihua Wang, Fen Liu, Qianqian Li, Dakui Luo, Jun Jiang, Hu Zhou, Yong Chen*, Jun Qin*, Daming Gao* (2025) Zinc Ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction, Oncogene 44, 8-18
  2. Xianle Shi#, Yanjing Li#, Hongwei Zhou#, Xiukun Hou#, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen*,Jianlong Wang* (2024) DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells , Nature Communications, 15,10803
  3. Wenqi Sun#, Qianhua Dong, Xueqing Li, Jinxin Gao, Xianwen Ye, Chunyi Hu, Fei Li*, Yong Chen* (2024) The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B, Nature Communications, 15, 4322
  4. Yue Weng, Xiangyu Yan, Biying Chen, Zhouliang Bian, Yunhui Ge, Hong Lu, Shufang He, Jian Wu, Yong Chen*, Ming Lei*, Yanjie Zhang* (2024) PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma, Genes & Diseases, https://doi.org/10.1016/j.gendis.2024.101319
  5. Jinxin Gao#, Wenqi Sun#, Jie Li, Hyoju Ban, Tuokai Zhang, Junwei Liao, Namho Kim, Soon Hoo Lee, Qianhua Dong, Robert Madramootoo, Yong Chen*, and Fei Li* (2023) Rex1BD and 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC, Proc. Natl. Acad. Sci. U S A.120(50) e2309359120
  6. Rekha Rai, Kevin Biju, Wenqi Sun, Tori Sodeinde, Amer AI-Hiysat, Jaida Morgan, Xianwen Ye, Xueqing Li, Yong Chen, and Sandy Chang (2023) Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1, Nature Communications, 14, 2144
  7. Minh Chau Nguyen#, Duo Wang#, Brianna J. Klein, Yong Chen*, Tatiana G. Kutateladze* (2023) Differences and similarities in recognition of co-factors by Taf14, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1856 (3):194961
  8. Min Chen#, Kangjunjie Wang#, Ying Han#, Shukun Yan#, Huairui Yuan, Qiuli Liu, Long Li, Ni Li, Hongwen Zhu, Dayun Lu, Kaihua Wang, Fen Liu, Dakui Luo, Yuxue Zhang, Jun Jiang, Dali Li, Lei Zhang, Hongbin Ji, Hu Zhou, Yong Chen*, Jun Qin, Daming Gao* (2023) Identification of XAF1 as an endogenous AKT inhibitor, Cell Reports, 42(7):112690
  9. Le Wu#, Ying Xu#, Wenqi Sun, Jun Sun, Yong Chen*, Lifeng Liu (2023) Melatonin plays a synergistic rather than a major role during osteogenic differentiation via MT2 in mouse mesenchymal stem cell line C3H10T1/2, Acta Biochemica et Biophysica Sinica, 55(9):1506-1510
  10. Naijin Zhang#, Ying Zhang#, Yong Chen, Hao Qian, Boquan Wu, Saien Lu 4 , Shilong You, Wancheng Xu, Yuanming Zou, Xinyue Huang, Wenbin Wang, Jingwei Liu, Da Li, Liu Cao, Yingxian Sun*（2023) BAF155 promotes cardiac hypertrophy and fibrosis through inbition of WWP2-mediated PARP1 ubiquitination, Cell Discovery, 9, 46
  11. Yanjing Li*, Kexue Ge, Tingting Li, Run Cai, Yong Chen* (2023) The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications, Protein & Cell, 14，165-179 (review)
  12. Yanjing Li#, Lijie Zhao#, Yuebin Zhang#, Ping Wu#, Ying Xu, Jun Mencius, Yongxin Zheng, Xiaoman Wang, Wancheng Xu, Naizhe Huang, Xianwen Ye, Ming Lei, Pan Shi, Changlin Tian, Chao Peng*, Guohui Li*, Zhijun Liu*, Shu Quan*, Yong Chen* (2022) Structural basis for product specificities of MLL family methyltransferases, Molecular Cell, 82, 3810-3825
  13. Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen (2022) DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, iScience, 25(9): 104948
  14. Duo Wang#, Fuxiang Yan#, Ping Wu#, Kexue Ge, Muchun Li, Tingting Li, Ying Gao, Chao Peng*, Yong Chen* (2022) Global profiling of regulatory elements in the histone benzoylation pathway, Nature Communications, 13:1369
  15. Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang (2021) Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres, Nature Communications, 12:5514
  16. Yongxin Zheng, Yinping Huang, Jun Mencius, Yanjing Li, Lijie Zhao, Wanting Luo, Yong Chen*, Shu Quan* (2021) Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes,  J. Biol. Chem. 100635
  17. Hyoju Ban, Wenqi Sun, Yu-hang Chen, Yong Chen, Fei Li (2021) Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation, Genetics , 218 (1): Iyab032
  18. Guochao Chen#, Duo Wang#, Bin Wu#, Fuxiang Yan, Hongjuan Xue, Shu Quan, Yong Chen (2020) Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Nature Communications, 11:4206
  19. Alessandro Cicconi, Rekha Rai, Xuexue Xiong, Cayla Broton, Amer Al-Hiyasat, Chunyi Hu, Siying Dong, Wenqi Sun, Jennifer Garbarino, Ranjit S. Bindra, Carl Schildkraut, Yong Chen*, Sandy Chang* (2020) Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly, Nature Communications, 11：5861
  20. Yanjing Li, Lijie Zhao, Xiaoxu Tian, Chao Peng, Fan Gong, Yong Chen (2020) Crystal structure of MLL2 complex guides the identification of a methylation site on P53 catalyzed by KMT2-family methyltransferases, Structure, 28(10):1141-1148
  21. Xia Chen, Yao Dong, Tianyue Guo, Chao-Yie Yang, Yong Chen and Haiying Sun (2020) N-terminal modified cyclopeptidic mimetics of ApolloTBM as inhibitors of TRF2. Bioorg Med Chem Lett 30(21):127401
  22. Tianyue Guo, Yao Dong, Yong Chen, Liu Liu, Haiying Sun (2020) Development and optimization of a cascade of screening assays for inhibitors of TRF2, Anal Biochem, 602: 113796     
  23. Xi Lin#, Mingyue Li#, Niandong Wang#, Yiran Wu#, Zhipu Luo, Shimeng Guo, Gye-Won Han, Shaobai Li, Yang Yue, Xiaohu Wei, Xin Xie, Yong Chen, Suwen Zhao, Jian Wu, Ming Lei, Fei Xu (2020) Structural basis of ligand recognition and self-activated of orphan GPR52, Nature, 579, 152-157
  24. Guochao Chen#, Wei Li#, Fuxiang Yan, Duo Wang, Yong Chen (2020) The structural basis for specific recognition of H3K14 acetylation by Sth1 in the RSC chromatin remodeling complex, Structure, 28(1):111-118
  25. Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwei Li, Ying Xu, Yong Chen (2019) The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 47(19):10426-10438
  26. Daphne Bazopoulou, Daniela Knoefler, Yongxin Zheng, Kathrin Ulrich, Bryndon J. Oleson, Lihan Xie, Minwook Kim, Anke Kaufmann , Young-Tae Lee, Yali Dou, Yong Chen, Shu Quan, and Ursula Jakob (2019),Developmental ROS individualizes organismal stress resistance and lifespan Nature, 576(7786):301-305
  27. Han Xue#, Tonghui Yao#, Mi Cao, Guanjun Zhu, Yan Li, Guiyong Yuan, Yong Chen, Ming Lei, and Jing Huang (2019) Structural basis of nucleosome recognition and modification by MLL methyltransferases, Nature, 573(7774):445-449
  28. Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang (2019) The Replisome mediates A-NHEJ repair of telomeres lacking POT1-TPP1 independent of MRN function, Cell Reports, 29(11):3708-3725
  29. Chunyi Hu#, Haruna Inoue#, Wenqi Sun#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 47(3): 1573-1584 (*co-corresponding author)
  30. Chunyi Hu#, Haruna Inoue#, Wenqi Sun#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) The inner nuclear membrane protein Bqt4 in fission yeast contains a DNA-binding domain essential for telomere association with the nuclear envelope, Structure, 27(2):335-343 (*co-corresponding author)
  31. Yong Chen (2019) The structural biology of the shelterin complex, Biol. Chem. 400(4):457-466 (Review)
  32. Qing Li#, Yanjing Li#, Suming Yang, Shuo Huang, Meng Yan,  Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen* and Jinsong Li* (2018) CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell Biol. 20(11): 1315-1325 (*co-corresponding author)
  33. Xia Chen, Liu Liu, Yong Chen, Yuting Yang, Chao-Yie Yang, Tianyue Guo, Ming Lei, Haiying Sun and Shaomeng Wang (2018) Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction, ACS Med Chem Lett, 9(5):507-511
  34. Chunyi Hu #, Rekha Rai #, Chenhui Huang, Cayla Broton, Juanjuan Long, Ying Xu, Jing Xue, Ming Lei* , Sandy Chang* and Yong Chen*（2017）Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 27(12):1485-1502  (*co-corresponding author)
  35. Jing Xue #, Hongwen Chen #, Jian Wu, Miho Takeuchi, Haruna Inoue, Yong Chen*, Junko Kanoh*, Ming Lei* (2017) Structure of the fission yeast S. pombe telomeric Poz1-Tpz1-Rap1 complex, Cell Research 27(12):1503-1520  (*co-corresponding author)
  36. Xiaoman Wang, Yiyue Zhao, Jian Zhang, and Yong Chen (2017) Structural basis for DAXX interaction with ATRX, Protein & Cell, 8(10):767-771
  37. Rekha Rai, Chunyi Hu, C Broton, Yong Chen, Ming Lei*, and Sandy Chang* (2017)  NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres, Mol Cell, 65, 801-817
  38. Hacer Karatas#, Yanbing Li#, Liu Liu#, Jiao Li#, Shirley Lee#, Yong Chen, Jiuling Yang, Liyue Huang, Denzil Bernard, Jing Xu, Elizabeth C. Townsend, Fang Cao, Xu Ran, Xiaoqin Li, Bo Wen, Duxin Sun, Jeanne A Stuckey, Ming Lei, Yali Dou, and Shaomeng Wang(2017) Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction, J.  Med. Chem, 60:4818-4839
  39. Yanjing Li, Jianming Han, Yuebin Zhang, Fang Cao, Zhijun Liu, Shuai Li, Jian Wu, Chunyi Hu, Yan Wang, Jin Shuai, Juan Chen, Liaoran Cao, Dangsheng Li, Pan Shi, Changlin Tian, Jian Zhang, Yali Dou, Guohui Li*, Yong Chen*, and Ming Lei＊(2016) Structural basis for activity regulation of MLL family methyltransferases，Nature, 530，447-452 (*co-corresponding author)
  40. Rekha Rai, Yong Chen, Ming Lei, and Sandy Chang (2016) TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions, Nat. Commun., 7: 10881, doi: 10.1038/ncomms10881
  41. Jinhu Yin#, Bingbing Wan#, Jaya Sarkar#, Kent Horvath, Jian Wu, Yong Chen, Guangjuan Cheng, Ke Wan, Peiju Chin, Ming Lei*, and Yie Liu* (2016) Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex, Nucleic Acids Research 44(10):4871-4880
  42. Xu Ran, Liu Liu, Chao-Yie Yang, Jianfeng Lu, Yong Chen, Ming Lei, Shaomeng Wang (2016) Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex, J. Med. Chem. 59, 328-334
  43. Yul W Yang#, Ryan A Flynn#, Yong Chen, Kun Qu, Bingbing Wan, Kevin C Wang, Ming Lei, Howard Y Chang (2014) Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency，Elife, Vol 3, e02046, 2014
  44. Fang Cao, Elizabeth C. Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu, Jay L. Hess, Peter Atadja, Ming Lei, Zhaohui S. Qin, Sami Malek, Shaomeng Wang*, Yali Dou* (2014) Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia, Mol. Cell, 53(2), 247-261
  45. Bingbing Wan#, Jinhu Yin#, Kent Horvath#, Jaya Sarkar, Yong Chen, Jian Wu, Ke Wan, Jian Lu, Peili Gu, Eun Young Yu, Neal F. Lue, Sandy Chang, Yie Liu* and Ming Lei* (2013) Slx4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres, Cell Reports, 4, 861-869
  46. Yanjing Li, Yong Chen (2014) Progress in structural and functional studies of histone methyltransferase MLL1, Chinese Journal of Cell Biology,36(7): 857–868 (Review in Chinese)
  47. Hacer Karatas#, Elizabeth C Townsend#, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou and Shaomeng Wang (2013) High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction, J. Am. Chem. Soc. 135(2): 669-682
  48. Yong Chen, Fang Cao, Bingbing, Yali Dou, Ming Lei (2012)Structure of the SPRY domain of Ash2L and its interactions with RbBP5 and DPY30, Cell Res.,  22(3):598-602
  49. Yong Chen#, Bingbing Wan#, Kevin C. Wang#, Fang Cao, Yuting Yang, Angeline Protacio, Yali Dou, Howard Y. Chang, Ming Lei (2011) Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding, EMBO Rep. 12(8),797-803
  50. Yong Chen# , Rekha Rai# , Zi-Ren Zhou , Junko Kanoh , Cyril Ribeyre , Yuting Yang , Hong Zheng , Pascal Damay , Feng Wang , Hisayo Tsujii, David Shore , Hong-Yu Hu , Sandy Chang* and Ming Lei* (2011) A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Nat. Struct. Mol. Biol., 18(2): 213-221
  51. Kevin Wang , Yul Yang , Rajnish Gupta , Angeline Protacio , Bo Liu , Jill Helms , Yong Chen , Ming Lei , Joanna Wysocka , Amartya Sanyal , Bryan Lajoie , Job Dekker , M. Corces-Zimmerman, Howard Chang (2011) A long noncoding RNA maintains active chromatin to coordinate homeotic gene express, Nature, 472(7341), 120-124
  52. Ying Tang#, Xijiang Pan#, Yong Chen, Phang C. Tai, Sen-Fang Sui (2011) Dimeric SecA couples the preprotein translocation in an asymmetric manner. PLoS One, 6(1), e16498
  53. Fang Cao#, Yong Chen#, Tomasz Cierpicki, Yifan Liu, Venkatesha Basrur, Ming Lei*, Yali Dou* (2010) An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One 5(11), e14102 (#Co-first author)
  54. Zhixiong Zeng#, Wei Wang#, Yuting Yang, Yong Chen,Xiaomei Yang, J.Alan Diehl, Xuedong Liu* and Ming Lei* (2010) Structural basis of selective ubiquitination of TRF1 bys SCFFBX4. Dev. Cell, 18, 214-225
  55. Yong Chen, Yuting Yang, Megan van Overbeek, Jill R. Donigian, Paul Baciu, Titia de Lange, Ming Lei (2008) A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins. Science, 319: 1092-1096
  56. Yong Chen#, Xijiang Pan#, Ying Tang, Shu Quan, Phang C. Tai, Sen-Fang Sui (2008) Full-length Escherichia coli SecA dimerizes in a closed conformation in solution as determined by cryo-electron microscopy. J. Biol. Chem. 283, 28783-28787
  57. Jiansen Jiang#, Xuefeng Zhang#, Yong Chen, Yi Wu, Z. Hong Zhou, Zengyi Chang*, Sen-Fang Sui* (2008) Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc. Natl. Acad. Sci. U S A. 105: 11939-11944
  58. Yong Chen, Phang C. Tai, Sen-Fang Sui (2007) The active ring-like structure of SecA revealed by electron crystallography: conformational change upon interaction with SecB. J. Struct. Biol. 159: 149-153
  59. Yong Chen, Yuting Yang, Feng Wang, Ke Wan, Kenichi Yamane, Yi Zhang, Ming Lei (2006) Crystal structure of human histone lysine-specific demethylase 1 (LSD1) . Proc. Natl. Acad. Sci. U S A. 103:13956-13961
  60. Shi-Zhen Wang#, Yong Chen#, Zhan-Hua Sun, Qiang Zhou, Sen-Fang Sui (2006) Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate. J. Biol. Chem. 281: 26813-26820 (#co-first author)
  61. Chang-Zhen Liu, Yong Chen and Sen-fang Sui, (2006) The identification of a new actin-binding region in p57. Cell Res., 16, 106-112
  62. Hong-Wei Wang#, Yong Chen#, Hsiuchin Yang, Xianchuan Chen, Ming-Xing Duan, Phang C. Tai* and Sen-fang Sui* (2003) Ring-like pore structures of SecA: implication for bacterial protein-conducting channels. Proc. Natl. Acad. Sci. U S A. 100, 4221-4226  (#Co-first author)
  63. Yong Chen, Ying-Jie Lu, Hong-Wei Wang, Shu Quan, Zengyi Chang and Sen-fang Sui, Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer, Biochem. Biophys. Res. Commun., 2003, 310: 360–366
  64. Yong Chen, Jinmei Song, Sen-fang Sui and Da-Neng Wang, DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli, Protein Expr. Purif., 2003, 32:221-231
  65. Da-Neng Wang, Markus Safferling, M. Joanne Lemieux, Heather Griffith, Yong Chen, Xiao-Dan Li(2003) Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies. Biochim. Biophy.s Acta. 1610:23-36. (Review)
  66. Da-Neng Wang,Yong Chen,Sen-Fang Sui(2003) Recent advance of electron microscopy and its applications in structural biology.   J. Chin. Elec. Micros. Soc. 22, 449-456 (Review in Chinese)
  67. Hong-Wei Wang, Yi Wu, Yong Chen and Sen-Fang Sui (2002)Polymorphism of structural forms of C-reactive protein. Int. J. Mol. Med. 9:665-671
  1. Kangjunjie Wang#, Min Chen#, Shukun Yan#, Ying Han, Huairui Yuan, Qiuli Liu, Dayun Lu, Long Li, Kaihua Wang, Fen Liu, Qianqian Li, Dakui Luo, Jun Jiang, Hu Zhou, Yong Chen*, Jun Qin*, Daming Gao* (2025) Zinc Ions activate AKT and promote prostate cancer cell proliferation via disrupting AKT intramolecular interaction, Oncogene 44, 8-18
  2. Xianle Shi#, Yanjing Li#, Hongwei Zhou#, Xiukun Hou#, Jihong Yang, Vikas Malik, Francesco Faiola, Junjun Ding, Xichen Bao, Miha Modic, Weiyu Zhang, Lingyi Chen, Syed Raza Mahmood, Effie Apostolou, Feng-Chun Yang, Mingjiang Xu, Wei Xie, Xin Huang, Yong Chen*,Jianlong Wang* (2024) DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells , Nature Communications, 15,10803
  3. Wenqi Sun#, Qianhua Dong, Xueqing Li, Jinxin Gao, Xianwen Ye, Chunyi Hu, Fei Li*, Yong Chen* (2024) The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B, Nature Communications, 15, 4322
  4. Yue Weng, Xiangyu Yan, Biying Chen, Zhouliang Bian, Yunhui Ge, Hong Lu, Shufang He, Jian Wu, Yong Chen*, Ming Lei*, Yanjie Zhang* (2024) PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma, Genes & Diseases, https://doi.org/10.1016/j.gendis.2024.101319
  1. Jinxin Gao#, Wenqi Sun#, Jie Li, Hyoju Ban, Tuokai Zhang, Junwei Liao, Namho Kim, Soon Hoo Lee, Qianhua Dong, Robert Madramootoo, Yong Chen*, and Fei Li* (2023) Rex1BD and 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC, Proc. Natl. Acad. Sci. U S A.120(50) e2309359120
  2. Rekha Rai, Kevin Biju, Wenqi Sun, Tori Sodeinde, Amer AI-Hiysat, Jaida Morgan, Xianwen Ye, Xueqing Li, Yong Chen, and Sandy Chang (2023) Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1, Nature Communications, 14, 2144
  3. Minh Chau Nguyen#, Duo Wang#, Brianna J. Klein, Yong Chen*, Tatiana G. Kutateladze* (2023) Differences and similarities in recognition of co-factors by Taf14, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1856 (3):194961
  4. Min Chen#, Kangjunjie Wang#, Ying Han#, Shukun Yan#, Huairui Yuan, Qiuli Liu, Long Li, Ni Li, Hongwen Zhu, Dayun Lu, Kaihua Wang, Fen Liu, Dakui Luo, Yuxue Zhang, Jun Jiang, Dali Li, Lei Zhang, Hongbin Ji, Hu Zhou, Yong Chen*, Jun Qin, Daming Gao* (2023) Identification of XAF1 as an endogenous AKT inhibitor, Cell Reports, 42(7):112690
  5. Le Wu#, Ying Xu#, Wenqi Sun, Jun Sun, Yong Chen*, Lifeng Liu (2023) Melatonin plays a synergistic rather than a major role during osteogenic differentiation via MT2 in mouse mesenchymal stem cell line C3H10T1/2, Acta Biochemica et Biophysica Sinica, 55(9):1506-1510
  6. Naijin Zhang#, Ying Zhang#, Yong Chen, Hao Qian, Boquan Wu, Saien Lu 4 , Shilong You, Wancheng Xu, Yuanming Zou, Xinyue Huang, Wenbin Wang, Jingwei Liu, Da Li, Liu Cao, Yingxian Sun*（2023) BAF155 promotes cardiac hypertrophy and fibrosis through inbition of WWP2-mediated PARP1 ubiquitination, Cell Discovery, 9, 46
  7. Yanjing Li*, Kexue Ge, Tingting Li, Run Cai, Yong Chen* (2023) The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications, Protein & Cell, 14，165-179 (review)
  1. Yanjing Li#, Lijie Zhao#, Yuebin Zhang#, Ping Wu#, Ying Xu, Jun Mencius, Yongxin Zheng, Xiaoman Wang, Wancheng Xu, Naizhe Huang, Xianwen Ye, Ming Lei, Pan Shi, Changlin Tian, Chao Peng*, Guohui Li*, Zhijun Liu*, Shu Quan*, Yong Chen* (2022) Structural basis for product specificities of MLL family methyltransferases, Molecular Cell, 82, 3810-3825
  2. Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen (2022) DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, iScience, 25(9): 104948
  3. Duo Wang#, Fuxiang Yan#, Ping Wu#, Kexue Ge, Muchun Li, Tingting Li, Ying Gao, Chao Peng*, Yong Chen* (2022) Global profiling of regulatory elements in the histone benzoylation pathway, Nature Communications, 13:1369
  1. Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer, Jayakrishnan Nandakumar, Yong Chen, Sandy Chang (2021) Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres, Nature Communications, 12:5514
  2. Yongxin Zheng, Yinping Huang, Jun Mencius, Yanjing Li, Lijie Zhao, Wanting Luo, Yong Chen*, Shu Quan* (2021) Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes,  J. Biol. Chem. 100635
  3. Hyoju Ban, Wenqi Sun, Yu-hang Chen, Yong Chen, Fei Li (2021) Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation, Genetics , 218 (1): Iyab032
  1. Guochao Chen#, Duo Wang#, Bin Wu#, Fuxiang Yan, Hongjuan Xue, Shu Quan, Yong Chen (2020) Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Nature Communications, 11:4206
  2. Alessandro Cicconi, Rekha Rai, Xuexue Xiong, Cayla Broton, Amer Al-Hiyasat, Chunyi Hu, Siying Dong, Wenqi Sun, Jennifer Garbarino, Ranjit S. Bindra, Carl Schildkraut, Yong Chen*, Sandy Chang* (2020) Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly, Nature Communications, 11：5861
  3. Yanjing Li, Lijie Zhao, Xiaoxu Tian, Chao Peng, Fan Gong, Yong Chen (2020) Crystal structure of MLL2 complex guides the identification of a methylation site on P53 catalyzed by KMT2-family methyltransferases, Structure, 28(10):1141-1148
  4. Xia Chen, Yao Dong, Tianyue Guo, Chao-Yie Yang, Yong Chen and Haiying Sun (2020) N-terminal modified cyclopeptidic mimetics of ApolloTBM as inhibitors of TRF2. Bioorg Med Chem Lett 30(21):127401
  5. Tianyue Guo, Yao Dong, Yong Chen, Liu Liu, Haiying Sun (2020) Development and optimization of a cascade of screening assays for inhibitors of TRF2, Anal Biochem, 602: 113796     
  6. Xi Lin#, Mingyue Li#, Niandong Wang#, Yiran Wu#, Zhipu Luo, Shimeng Guo, Gye-Won Han, Shaobai Li, Yang Yue, Xiaohu Wei, Xin Xie, Yong Chen, Suwen Zhao, Jian Wu, Ming Lei, Fei Xu (2020) Structural basis of ligand recognition and self-activated of orphan GPR52, Nature, 579, 152-157
  7. Guochao Chen#, Wei Li#, Fuxiang Yan, Duo Wang, Yong Chen (2020) The structural basis for specific recognition of H3K14 acetylation by Sth1 in the RSC chromatin remodeling complex, Structure, 28(1):111-118
  1. Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwei Li, Ying Xu, Yong Chen (2019) The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 47(19):10426-10438
  2. Daphne Bazopoulou, Daniela Knoefler, Yongxin Zheng, Kathrin Ulrich, Bryndon J. Oleson, Lihan Xie, Minwook Kim, Anke Kaufmann , Young-Tae Lee, Yali Dou, Yong Chen, Shu Quan, and Ursula Jakob (2019),Developmental ROS individualizes organismal stress resistance and lifespan Nature, 576(7786):301-305
  3. Han Xue#, Tonghui Yao#, Mi Cao, Guanjun Zhu, Yan Li, Guiyong Yuan, Yong Chen, Ming Lei, and Jing Huang (2019) Structural basis of nucleosome recognition and modification by MLL methyltransferases, Nature, 573(7774):445-449
  4. Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang (2019) The Replisome mediates A-NHEJ repair of telomeres lacking POT1-TPP1 independent of MRN function, Cell Reports, 29(11):3708-3725
  5. Chunyi Hu#, Haruna Inoue#, Wenqi Sun#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 47(3): 1573-1584 (*co-corresponding author)
  6. Chunyi Hu#, Haruna Inoue#, Wenqi Sun#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) The inner nuclear membrane protein Bqt4 in fission yeast contains a DNA-binding domain essential for telomere association with the nuclear envelope, Structure, 27(2):335-343 (*co-corresponding author)
  7. Yong Chen (2019) The structural biology of the shelterin complex, Biol. Chem. 400(4):457-466 (Review)
  1. Qing Li#, Yanjing Li#, Suming Yang, Shuo Huang, Meng Yan,  Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen* and Jinsong Li* (2018) CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell Biol. 20(11): 1315-1325 (*co-corresponding author)
  2. Xia Chen, Liu Liu, Yong Chen, Yuting Yang, Chao-Yie Yang, Tianyue Guo, Ming Lei, Haiying Sun and Shaomeng Wang (2018) Cyclic Peptidic Mimetics of Apollo Peptides Targeting Telomeric Repeat Binding Factor 2 (TRF2) and Apollo Interaction, ACS Med Chem Lett, 9(5):507-511
  1. Chunyi Hu #, Rekha Rai #, Chenhui Huang, Cayla Broton, Juanjuan Long, Ying Xu, Jing Xue, Ming Lei* , Sandy Chang* and Yong Chen*（2017）Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 27(12):1485-1502  (*co-corresponding author)
  2. Jing Xue #, Hongwen Chen #, Jian Wu, Miho Takeuchi, Haruna Inoue, Yong Chen*, Junko Kanoh*, Ming Lei* (2017) Structure of the fission yeast S. pombe telomeric Poz1-Tpz1-Rap1 complex, Cell Research 27(12):1503-1520  (*co-corresponding author)
  3. Xiaoman Wang, Yiyue Zhao, Jian Zhang, and Yong Chen (2017) Structural basis for DAXX interaction with ATRX, Protein & Cell, 8(10):767-771
  4. Rekha Rai, Chunyi Hu, C Broton, Yong Chen, Ming Lei*, and Sandy Chang* (2017)  NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres, Mol Cell, 65, 801-817
  5. Hacer Karatas#, Yanbing Li#, Liu Liu#, Jiao Li#, Shirley Lee#, Yong Chen, Jiuling Yang, Liyue Huang, Denzil Bernard, Jing Xu, Elizabeth C. Townsend, Fang Cao, Xu Ran, Xiaoqin Li, Bo Wen, Duxin Sun, Jeanne A Stuckey, Ming Lei, Yali Dou, and Shaomeng Wang(2017) Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction, J.  Med. Chem, 60:4818-4839
  1. Yanjing Li, Jianming Han, Yuebin Zhang, Fang Cao, Zhijun Liu, Shuai Li, Jian Wu, Chunyi Hu, Yan Wang, Jin Shuai, Juan Chen, Liaoran Cao, Dangsheng Li, Pan Shi, Changlin Tian, Jian Zhang, Yali Dou, Guohui Li*, Yong Chen*, and Ming Lei＊(2016) Structural basis for activity regulation of MLL family methyltransferases，Nature, 530，447-452 (*co-corresponding author)
  2. Rekha Rai, Yong Chen, Ming Lei, and Sandy Chang (2016) TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions, Nat. Commun., 7: 10881, doi: 10.1038/ncomms10881
  3. Jinhu Yin#, Bingbing Wan#, Jaya Sarkar#, Kent Horvath, Jian Wu, Yong Chen, Guangjuan Cheng, Ke Wan, Peiju Chin, Ming Lei*, and Yie Liu* (2016) Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex, Nucleic Acids Research 44(10):4871-4880
  4. Xu Ran, Liu Liu, Chao-Yie Yang, Jianfeng Lu, Yong Chen, Ming Lei, Shaomeng Wang (2016) Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex, J. Med. Chem. 59, 328-334
  1. Yul W Yang#, Ryan A Flynn#, Yong Chen, Kun Qu, Bingbing Wan, Kevin C Wang, Ming Lei, Howard Y Chang (2014) Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency，Elife, Vol 3, e02046, 2014
  2. Fang Cao, Elizabeth C. Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu, Jay L. Hess, Peter Atadja, Ming Lei, Zhaohui S. Qin, Sami Malek, Shaomeng Wang*, Yali Dou* (2014) Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia, Mol. Cell, 53(2), 247-261
  3. Bingbing Wan#, Jinhu Yin#, Kent Horvath#, Jaya Sarkar, Yong Chen, Jian Wu, Ke Wan, Jian Lu, Peili Gu, Eun Young Yu, Neal F. Lue, Sandy Chang, Yie Liu* and Ming Lei* (2013) Slx4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres, Cell Reports, 4, 861-869
  4. Yanjing Li, Yong Chen (2014) Progress in structural and functional studies of histone methyltransferase MLL1, Chinese Journal of Cell Biology,36(7): 857–868 (Review in Chinese)
  1. Hacer Karatas#, Elizabeth C Townsend#, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou and Shaomeng Wang (2013) High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction, J. Am. Chem. Soc. 135(2): 669-682
  2. Yong Chen, Fang Cao, Bingbing, Yali Dou, Ming Lei (2012)Structure of the SPRY domain of Ash2L and its interactions with RbBP5 and DPY30, Cell Res.,  22(3):598-602
  3. Yong Chen#, Bingbing Wan#, Kevin C. Wang#, Fang Cao, Yuting Yang, Angeline Protacio, Yali Dou, Howard Y. Chang, Ming Lei (2011) Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding, EMBO Rep. 12(8),797-803
  4. Yong Chen# , Rekha Rai# , Zi-Ren Zhou , Junko Kanoh , Cyril Ribeyre , Yuting Yang , Hong Zheng , Pascal Damay , Feng Wang , Hisayo Tsujii, David Shore , Hong-Yu Hu , Sandy Chang* and Ming Lei* (2011) A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Nat. Struct. Mol. Biol., 18(2): 213-221
  5. Kevin Wang , Yul Yang , Rajnish Gupta , Angeline Protacio , Bo Liu , Jill Helms , Yong Chen , Ming Lei , Joanna Wysocka , Amartya Sanyal , Bryan Lajoie , Job Dekker , M. Corces-Zimmerman, Howard Chang (2011) A long noncoding RNA maintains active chromatin to coordinate homeotic gene express, Nature, 472(7341), 120-124
  6. Ying Tang#, Xijiang Pan#, Yong Chen, Phang C. Tai, Sen-Fang Sui (2011) Dimeric SecA couples the preprotein translocation in an asymmetric manner. PLoS One, 6(1), e16498
  7. Fang Cao#, Yong Chen#, Tomasz Cierpicki, Yifan Liu, Venkatesha Basrur, Ming Lei*, Yali Dou* (2010) An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One 5(11), e14102 (#Co-first author)
  8. Zhixiong Zeng#, Wei Wang#, Yuting Yang, Yong Chen,Xiaomei Yang, J.Alan Diehl, Xuedong Liu* and Ming Lei* (2010) Structural basis of selective ubiquitination of TRF1 bys SCFFBX4. Dev. Cell, 18, 214-225
  9. Yong Chen, Yuting Yang, Megan van Overbeek, Jill R. Donigian, Paul Baciu, Titia de Lange, Ming Lei (2008) A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins. Science, 319: 1092-1096
  10. Yong Chen#, Xijiang Pan#, Ying Tang, Shu Quan, Phang C. Tai, Sen-Fang Sui (2008) Full-length Escherichia coli SecA dimerizes in a closed conformation in solution as determined by cryo-electron microscopy. J. Biol. Chem. 283, 28783-28787
  11. Jiansen Jiang#, Xuefeng Zhang#, Yong Chen, Yi Wu, Z. Hong Zhou, Zengyi Chang*, Sen-Fang Sui* (2008) Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc. Natl. Acad. Sci. U S A. 105: 11939-11944
  12. Yong Chen, Phang C. Tai, Sen-Fang Sui (2007) The active ring-like structure of SecA revealed by electron crystallography: conformational change upon interaction with SecB. J. Struct. Biol. 159: 149-153
  13. Yong Chen, Yuting Yang, Feng Wang, Ke Wan, Kenichi Yamane, Yi Zhang, Ming Lei (2006) Crystal structure of human histone lysine-specific demethylase 1 (LSD1) . Proc. Natl. Acad. Sci. U S A. 103:13956-13961
  14. Shi-Zhen Wang#, Yong Chen#, Zhan-Hua Sun, Qiang Zhou, Sen-Fang Sui (2006) Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate. J. Biol. Chem. 281: 26813-26820 (#co-first author)
  15. Chang-Zhen Liu, Yong Chen and Sen-fang Sui, (2006) The identification of a new actin-binding region in p57. Cell Res., 16, 106-112
  16. Hong-Wei Wang#, Yong Chen#, Hsiuchin Yang, Xianchuan Chen, Ming-Xing Duan, Phang C. Tai* and Sen-fang Sui* (2003) Ring-like pore structures of SecA: implication for bacterial protein-conducting channels. Proc. Natl. Acad. Sci. U S A. 100, 4221-4226  (#Co-first author)
  17. Yong Chen, Ying-Jie Lu, Hong-Wei Wang, Shu Quan, Zengyi Chang and Sen-fang Sui, Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer, Biochem. Biophys. Res. Commun., 2003, 310: 360–366
  18. Yong Chen, Jinmei Song, Sen-fang Sui and Da-Neng Wang, DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli, Protein Expr. Purif., 2003, 32:221-231
  19. Da-Neng Wang, Markus Safferling, M. Joanne Lemieux, Heather Griffith, Yong Chen, Xiao-Dan Li(2003) Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies. Biochim. Biophy.s Acta. 1610:23-36. (Review)
  20. Da-Neng Wang,Yong Chen,Sen-Fang Sui(2003) Recent advance of electron microscopy and its applications in structural biology.   J. Chin. Elec. Micros. Soc. 22, 449-456 (Review in Chinese)
  21. Hong-Wei Wang, Yi Wu, Yong Chen and Sen-Fang Sui (2002)Polymorphism of structural forms of C-reactive protein. Int. J. Mol. Med. 9:665-671