2005.5-2012.8      美国密歇根大学医学院生物化学系，博士后

2012.8- 至今         中国科学院生物化学与细胞生物学研究所/分子细胞科学卓越创新中心，研究员，博士生导师

2015.3-至今          上海科技大学兼职教授

2023.5-至今          国科大杭州高等研究院兼职研究员

中国生物化学与分子生物学会理事

中国生物化学与分子生物学会基因专业分会秘书长

先后获得中科院战略先导项目、科技部重点研发计划、自然科学基金委面上项目、上海市基础研究特区计划、上海市科委基础重点项目等项目的支持。入选海外高层次人才引进计划（青年）、国家高层次人才特殊支持计划科技创新领军人才。

2016   中科院优秀导师

2018   中科院优秀导师

2020   中科院优秀导师

2022   中科院优秀导师

1. Wenqi Sun#, Qianhua Dong, Xueqing Li, Jinxin Gao, Xianwen Ye, Chunyi Hu, Fei Li*, Yong Chen* (2024) The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B, Nature Communications, 15, 4322
2. Yanjing Li#, Lijie Zhao#, Yuebin Zhang#, Ping Wu#, Ying Xu, Jun Mencius, Yongxin Zheng, Xiaoman Wang, Wancheng Xu, Naizhe Huang, Xianwen Ye, Ming Lei, Pan Shi, Changlin Tian, Chao Peng*, Guohui Li*, Zhijun Liu*, Shu Quan*, Yong Chen* (2022) Structural basis for product specificities of MLL family methyltransferases, Molecular Cell, 82, 3810-3825
3. Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen (2022) DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, iScience, 25(9): 104948
4. Duo Wang#, Fuxiang Yan#, Ping Wu#, Kexue Ge, Muchun Li, Tingting Li, Ying Gao, Chao Peng*, Yong Chen* (2022) Global profiling of regulatory elements in the histone benzoylation pathway, Nature Communication, 13：1369
5. Guochao Chen#, Duo Wang#, Bin Wu#, Fuxiang Yan, Hongjuan Xue, Shu Quan, Yong Chen* (2020) Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Nature Communication, 11:4206
6. Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwei Li, Ying Xu, Yong Chen* (2019) The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 47(19):10426-10438
7. Chunyi Hu^#, Haruna Inoue^#, Wenqi Sun^#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 47(3): 1573-1584 (*co-corresponding author)
8. Qing Li^#, Yanjing Li^#, Suming Yang, Shuo Huang, Meng Yan,  Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen* and Jinsong Li* (2018) CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell Biol. 20(11): 1315-1325 (*co-corresponding author)
9. Chunyi Hu ^#, Rekha Rai ^#, Chenhui Huang, Cayla Broton, Juanjuan Long, Ying Xu, Jing Xue, Ming Lei* , Sandy Chang* and Yong Chen*（2017）Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 27(12):1485-1502  (*co-corresponding author)
10. Yanjing Li, Jianming Han, Yuebin Zhang, Fang Cao, Zhijun Liu, Shuai Li, Jian Wu, Chunyi Hu, Yan Wang, Jin Shuai, Juan Chen, Liaoran Cao, Dangsheng Li, Pan Shi, Changlin Tian, Jian Zhang, Yali Dou, Guohui Li*, Yong Chen^*, and Ming Lei*(2016) Structural basis for activity regulation of MLL family methyltransferases，Nature, 530，447-452 (*co-corresponding author)
11. Yong Chen^# , Rekha Rai^# , Zi-Ren Zhou , Junko Kanoh , Cyril Ribeyre , Yuting Yang , Hong Zheng , Pascal Damay , Feng Wang , Hisayo Tsujii, David Shore , Hong-Yu Hu , Sandy Chang* and Ming Lei* (2011) A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Nat. Struct. Mol. Biol., 18(2): 213-221
12. Yong Chen, Yuting Yang, Megan van Overbeek, Jill R. Donigian, Paul Baciu, Titia de Lange, Ming Lei (2008) A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins. Science, 319: 1092-1096
13. Yong Chen, Yuting Yang, Feng Wang, Ke Wan, Kenichi Yamane, Yi Zhang, Ming Lei (2006) Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc. Natl. Acad. Sci. U S A. 103:13956-13961